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KMID : 0620920070390030304
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Experimental & Molecular Medicine
2007 Volume.39 No. 3 p.304 ~ p.315
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Effects of retinoic acid on ischemic brain injury-induced neurogenesis
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Jung Dae-Soo
Baek Sun-Yong
Park Kyu-Hyun
Jung Young-In
Kim Hak-Jin
Kim Chi-Dae
Cho Min-Kyoung
Han Myong-Eun
Park Kyung-Phil
Kim Bong-Seon
Kim Jae-Bong
Oh Sae-Ock
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Abstract
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Neurogenesis can be induced by pathological conditions such as cerebral ischemia. However the molecular mechanisms or modulating reagents of the reactive neurogenesis after the cerebral ischemia are poorly characterized. Retinoic acid (RA) has been shown to increase neurogenesis by enhancing the proliferation and neuronal differentiation of forebrain neuroblasts. Here, we examined whether RA can modulate the reactive neurogenesis after the cerebral ischemia. In contrast to our expectation, RA treatment decreased the reactive neurogenesis in subventricular zone (SVZ), subgranular zone (SGZ) and penumbral region. Furthermore, RA treatment also decreased the angiogenesis and gliosis in penumbral region.
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KEYWORD
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angiogenesis, cerebral infarction, gliosis, tretinoin
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